Specific Chemicals Program

There are a number of hazardous chemicals commonly used in biomedical research for which a biological use application (BUA) is required. These include carcinogens, chemotherapy agents, toxins of biological origin, and other chemicals that are deemed hazardous by the IBC, biosafety, or another authority. Biosafety performs a risk assessment and requires an exposure control plan or SOP for these agents. When there is a medical intervention that can be applied prior to exposure or a process for medical care upon exposure that can be developed ahead of time, the Occupational Medicine Program provides access to it for employees.

Not all chemicals used in biomedical research have a prophylactic measure such as an immunization. However, all chemical exposures, even small ones, must be reported to one’s supervisor. The supervisor is responsible to complete a manager’s incident report and to ensure that an injured employee seeks medical attention promptly.

BUA-Required Chemical Pre- and Post-Exposure Processes

Chemical

Research Role

Pre-Exposure Process

Post-Exposure Process

MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)

A neurotoxin that causes Parkinson’s-like symptoms

  • ECP, SOP, SDS
  • Animal bedding SOP
  • Physical and health history
  • Prescription for eldepryl/selegiline
  • Work with this agent requires approval by physician
  • Follow ECP
  • Seek medical attention immediately
  • Medication under a physician’s care

ENU  N-ethyl-N-nitrosourea

Potent mutagen

  • ECP, SOP, SDS
  • Animal bedding SOP
  • Follow ECP
  • Seek medical attention immediately

Pertussis toxin
Diphtheria toxin
Tetanus toxin

  • Used in the development of animal models for human disease
  • Other uses in biomedical research
  • ECP, SOP, SDS
  • Animal bedding SOP
  • Vaccine
  • Follow ECP
  • Seek medical attention
  • Antitoxin may be available

Other toxins of biological origin, e.g.
Tetrodotoxin
Conotoxin, SEB, others

Various uses in biomedical research

  • ECP, SOP, SDS
  • Animal bedding SOP
  • Follow ECP
  • Seek medical attention

Carcinogens
(Prop 65 list)

Various uses in biomedical research

  • ECP, SOP, SDS
  • Animal bedding SOP
  • Follow ECP
  • Seek medical attention

Chemotherapy agents

Various uses in biomedical research

  • ECP, SOP, SDS
  • Animal bedding SOP
  • Follow ECP
  • Seek medical attention

Streptozoticin

Induces diabetes in mice

  • ECP, SOP, SDS
  • Animal bedding SOP
  • Follow ECP
  • Seek medical attention

Pertussis toxin
Diphtheria toxin
Tetanus toxin

  • Used in the development of animal models for human disease
  • Other uses in biomedical research
  • ECP, SOP, SDS
  • Animal bedding SOP
  • Vaccine
  • Follow ECP
  • Seek medical attention
  • Antitoxin may be available

Other toxins of biological origin, e.g.
Tetrodotoxin
Conotoxin, SEB, others

Various uses in biomedical research

  • ECP, SOP, SDS
  • Animal bedding SOP
  • Follow ECP
  • Seek medical attention